Idiopathic hypercalcemia in cats

Idiopathic hypercalcemia in cats

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Idiopathic hypercalcemia in cats with the PTH resistance syndrome: a case series.

To describe the presenting clinical signs, signalment, and treatment of cats with iatrogenic hypocalcemia and iatrogenic hypercalcemia resulting from primary hypoparathyroidism, secondary hypoparathyroidism, primary hyperparathyroidism, and hypercalcemia from drug-induced hypercalcemia (tamoxifen, pamidronate, and cinacalcet hydrochloride) that were not responsive to conventional therapy. Medical records were reviewed for client-owned cats treated from January 1, 2006, to August 31, 2017, at a private referral hospital. Four client-owned cats, ranging in age from 3 to 11 years, were identified with iatrogenic hypocalcemia or hypercalcemia. One cat with iatrogenic hypercalcemia was euthanized secondary to a life-limiting disease that could not be treated. Hypercalcemia associated with drug-induced PTH resistance is not uncommon in cats, although it is typically refractory to conventional therapy. As a result, cats with iatrogenic hypercalcemia and PTH resistance may benefit from an alternative medical approach to therapy. In addition to the cat in this report, 2 of the 4 cats responded to treatment with calcitonin. Hypercalcemia and PTH resistance should be considered a differential diagnosis for cats with iatrogenic hypocalcemia or hypercalcemia that is not responsive to conventional treatment. Cats with iatrogenic hypercalcemia and PTH resistance may respond to treatment with calcitonin.

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